Regulatory B cells and transplantation: almost prime time?
نویسندگان
چکیده
منابع مشابه
Regulatory B-Cells in Transplantation
B-cells have been long accepted as the main cellular component in humoral responses. Their effector function is based on antibody and cytokine production. The development of donor-specific antibodies by B-cells has deleterious consequences in graft and patients survival. Recently, a new subset of IL-10-secreting B-cells with regulatory capacity in allergic and autoimmune diseases has been shown...
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Let $R$ be a commutative ring with identity. A proper ideal $P$ of $R$ is a $(n-1,n)$-$Phi_m$-prime ($(n-1,n)$-weakly prime) ideal if $a_1,ldots,a_nin R$, $a_1cdots a_nin Pbackslash P^m$ ($a_1cdots a_nin Pbackslash {0}$) implies $a_1cdots a_{i-1}a_{i+1}cdots a_nin P$, for some $iin{1,ldots,n}$; ($m,ngeq 2$). In this paper several results concerning $(n-1,n)$-$Phi_m$-prime and $(n-1,n)$-...
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Granzyme B (GZB) has been implicated as an effector mechanism in regulatory T cells (T(reg)) suppression. In a model of T(reg)-dependent graft tolerance, it is shown that GZB- deficient mice are unable to establish long-term tolerance. Moreover, mice overexpressing the inhibitor of GZB, serine protease inhibitor 6, are also resistant to tolerization to alloantigen. Graft survival was shorter in...
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Induction of tolerance remains a major goal in transplantation. Indeed, despite potent immunosuppression, chronic rejection is still a real problem in transplantation. The humoral response is an important mediator of chronic rejection, and numerous strategies have been developed to target either B cells or plasma cells. However, the use of anti-CD20 therapy has highlighted the beneficial role o...
متن کاملon generalisations of almost prime and weakly prime ideals
let $r$ be a commutative ring with identity. a proper ideal $p$ of $r$ is a $(n-1,n)$-$phi_m$-prime ($(n-1,n)$-weakly prime) ideal if $a_1,ldots,a_nin r$, $a_1cdots a_nin pbackslash p^m$ ($a_1cdots a_nin pbackslash {0}$) implies $a_1cdots a_{i-1}a_{i+1}cdots a_nin p$, for some $iin{1,ldots,n}$; ($m,ngeq 2$). in this paper several results concerning $(n-1,n)$-$phi_m$-prime and $(n-1,n)$-...
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ژورنال
عنوان ژورنال: Current Opinion in Organ Transplantation
سال: 2018
ISSN: 1087-2418,1531-7013
DOI: 10.1097/mot.0000000000000559